The Effect of Erythropoietin at the Time of Reperfusion in Acute Myocardial Infarction

Phase 4 Completed 58 enrolled Seoul National University Bundang Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to investigate the effect of intravenous human recombinant erythropoietin on the reperfusion injury at primary percutaneous coronary intervention in patients with acute myocardial infarction.

Timeline

Start: 2008-05
Primary completion: 2009-02
Completion: 2009-02

Outcome

Missed primary endpoint

paper EPO group 52.4 ± 23.6 cm(3) vs. control group 54.8 ± 28.6 cm(3), p=0.74 PMID 20199815 ↗

paper However, it did not reduce the infarct size when assessed by MRI and cardiac enzyme. PMID 20199815 ↗

Publications

Suh JW, Chung WY, Kim YS, Kim KI, Jeon EJ, Cho YS, Youn TJ, Chae IH, Kim CH, Choi DJ. The effect of intravenous administration of erythropoietin on the infarct size in primary percutaneous coronary intervention. Int J Cardiol. 2011 Jun 2;149(2):216-220. doi: 10.1016/j.ijcard.2010.02.002. Epub 2010 Mar 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	epoetin alfa	Protein / enzyme biologic	50 iu/kg	Intravenous