Single Photon Emission Computed Tomography (SPECT) Imaging Study to Develop a Biomarker for Alzheimer's Disease

Summary

The main objectives of this proposal are as follows: * To assess the dynamic uptake and washout of 123-I MNI-388 and MNI 390, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in similarly aged Alzheimer's (AD) subjects and healthy controls * To perform blood metabolite characterization of 123-I MNI-388 and MNI-390 in healthy and AD subjects to determine the metabolic fate and nature of metabolites in assessment of 123-I MNI-388 and MNI 390 as a single photon computed tomography (SPECT) brain imaging agent

Timeline

Start

2009-03

Primary completion

2009-03

Completion

2009-03

Outcome

Outcome not reported

Stopped: “There seemed to be no uptake of the ligand in the areas of the brain expected for subjects with amyloid.”

Drugs

Indications