Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

Phase 4 Completed 5 enrolled Uppsala University Swedish Parkinson's Disease Foundation · collab Swedish Society for Medical Research · collab

Non-randomizedSingle-groupDouble-blindTreatment

Summary

The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.

Timeline

Start: 2008-02
Primary completion: 2008-05
Completion: 2008-05

Publications

Background Nyholm D, Nilsson Remahl AI, Dizdar N, Constantinescu R, Holmberg B, Jansson R, Aquilonius SM, Askmark H. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease. Neurology. 2005 Jan 25;64(2):216-23. doi: 10.1212/01.WNL.0000149637.70961.4C.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	levodopa/carbidopa	Unknown	—	Other

Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

Summary

Timeline

Publications

Drugs

Indications