Nutritional and Contractile Regulation of Muscle Growth

Phase 1 Completed 144 enrolled The University of Texas Medical Branch, Galveston National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · collab

RandomizedFactorialDouble-blindBasic science

Summary

Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis. It is also prevalent among the elderly and in people who experience periods of physical inactivity and weightlessness. Muscle wasting can lead to overall weakness, immobility, physical dependence, and a greater risk of death when exposed to infection, surgery, or trauma. There is a need to develop scientifically based treatments that prevent muscle wasting. As one step towards such a goal, this study will examine the physiological and cellular mechanisms that regulate skeletal muscle growth.

Timeline

Start: 2009-04
Primary completion: 2015-03
Completion: 2015-03

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Sirolimus	Small molecule	16 mg	Oral
Comparator	Sodium Nitroprusside	Unknown	—	Other

Nutritional and Contractile Regulation of Muscle Growth

Summary

Timeline

Publications

Drugs

Indications