drugset / Trial / NCT00892385
Methoxyamine and Temozolomide in Treating Patients With Advanced Solid Tumors
Phase 1
Completed
66 enrolled
Case Comprehensive Cancer Center
National Cancer Institute (NCI) · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy, such as methoxyamine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving methoxyamine together with temozolomide may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of methoxyamine when given together with temozolomide in treating patients with advanced solid tumors.
Timeline
- Start
- 2007-08-16
- Primary completion
- 2017-03-08
- Completion
- 2017-03-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methoxyamine | Small molecule | — | Intravenous |
| Subject | Temozolomide | Small molecule | — | Oral |