Riluzole in Fragile X Syndrome

Phase 4 Completed 6 enrolled Indiana University Indiana Clinical and Translational Sciences Institute · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to investigate the effectiveness and tolerability of riluzole in adults with Fragile X Syndrome.

Timeline

Start: 2009-04
Primary completion: 2010-07
Completion: 2010-07

Outcome

Missed primary endpoint

paper CONCLUSION: Overall, riluzole use was not associated with significant clinical improvement despite uniform correction of peripheral ERK activation. PMID 21059347 ↗

Publications

Results Erickson CA, Weng N, Weiler IJ, Greenough WT, Stigler KA, Wink LK, McDougle CJ. Open-label riluzole in fragile X syndrome. Brain Res. 2011 Mar 22;1380:264-70. doi: 10.1016/j.brainres.2010.10.108. Epub 2010 Nov 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Riluzole	Small molecule	50 mg	—