drugset / Trial / NCT00895804
Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)
Phase 1
Completed
16 enrolled
University Hospital, Basel, Switzerland
Heffter Research Institute · collab
RandomizedCrossoverQuadruple-blindBasic science
Summary
MDMA (3,4-Methylenedioxymethamphetamine, "Ecstasy") produces tachycardia, hypertension, hyperthermia, and other acute adverse effects. Ecstasy use has also been associated with rare cardio- and cerebrovascular complications. The role of beta-blockers in the treatment of cardiovascular and adverse effects of MDMA is unknown.
Timeline
- Start
- 2001-06
- Primary completion
- 2002-03
- Completion
- 2002-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 3,4-Methylenedioxymethamphetamine | Unknown | 1.6 mg/kg | — |
| Subject | Pindolol | Small molecule | 20 mg | — |