drugset / Trial / NCT00901550
The Chinese University of Hong Kong Early Arthritis Study
RandomizedSingle-groupOpen-labelTreatment
Summary
The purpose of this study is: 1. To ascertain whether the quantitative assessment of enhancing synovial volume and perfusion indices on serial Magnetic Resonance Imaging (MRI) examination are useful indicators of responsiveness to treatment in early Rheumatoid Arthritis (RA) using biologic therapy and Methotrexate (MTX) compared with Methotrexate(MTX) alone. 2. To assess the cost-effectiveness of Tumor Necrosis Factor (TNF) blockers compared with Methotrexate(MTX) monotherapy for Rheumatoid Arthritis(RA).
Timeline
- Start
- 2008-11
- Primary completion
- 2011-10
- Completion
- 2011-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Infliximab | Monoclonal antibody | 3 mg/kg | — |
| Comparator | Methotrexate | Small molecule | 15 mg | Oral |
| Comparator | Methotrexate | Small molecule | 20 mg | Oral |