drugset / Trial / NCT00903708
LY2275796 in Advanced Cancer
Non-randomizedSingle-groupOpen-labelTreatment
Summary
Primary Objective: * To determine a recommended Phase 2 dose of LY2275796 that may be safely administered to patients with advanced cancer, with prospects for therapeutic biologic effects. This will require simultaneous: * monitoring of toxicities \& determination of maximal tolerated dose (MTD) * detecting eIF-4E target inhibition in tumor * pharmacokinetic measurements Secondary Objectives: * To estimate pharmacokinetic parameters of LY2275796 and explore pharmacokinetic/pharmacodynamic relationships * To document any antitumor activity observed with LY2275796
Timeline
- Start
- 2006-09
- Primary completion
- 2010-06
- Completion
- 2010-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | LY2275796 | Unknown | 100 mg | Intravenous |