drugset / Trial / NCT00904657
An Explorative Study on the Pharmacokinetics and Pharmacodynamics of Sunitinib in Healthy Volunteers
Phase 1
Completed
12 enrolled
University of Cologne
University Hospital, Bonn · collabZKS Köln · collab
Non-randomizedSingle-groupOpen-labelBasic science
Summary
The study is conducted: * to investigate the influence of sunitinib (study drug) on the plasma biomarkers VEGF-A, VEGF-C, soluble VEGFR-2, and soluble VEGFR-3 (vessel endothelial growth factors) and on the blood pressure; * to generate a pharmacokinetic/pharmacodynamic model for sunitinib using biomarkers.
Timeline
- Start
- 2008-10
- Primary completion
- 2009-04
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Sunitinib | Small molecule | 50 mg | — |