drugset / Trial / NCT00905762
Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After Topical Instillation
RandomizedParallel-groupDouble-blindScreening
Summary
The purpose of this study is to assess the concentration of besifloxacin compared to gatifloxacin and moxifloxacin in human conjunctival tissue, following a single drop of the drug instilled topically into the study eye. Conjunctival biopsies will be performed at specified time points, followed by the use of loteprednol etabonate/tobramycin ophthalmic suspension four times a day for 5 days.
Timeline
- Start
- 2009-03
- Primary completion
- 2009-04
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Besifloxacin | Small molecule | 0.6 % | Topical |
| Comparator | Gatifloxacin | Small molecule | 0.3 % | Topical |
| Comparator | Moxifloxacin | Small molecule | 0.5 % | Topical |
Indications
No indication recorded.