drugset / Trial / NCT00907985
A Study to Evaluate the Effect of Single Doses of Drug A (Lamotrigine) and Drug B (Vofopitant) Alone and in Combination on Resting Motor Threshold in Healthy Subjects
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to investigate the effect of drug A on its own and when it is given in combination with drug B on markers of brain activity. The study will 1. Assess the effects of drug A and drug B on muscle movement after brain stimulation; 2. Examine how the body handles (absorbs, distributes, breaks down and gets rid of) drug A and drug B when given in combination; 3. Examine the safety of drug A and drug B when given together.
Timeline
- Start
- 2009-05-15
- Primary completion
- 2010-06-10
- Completion
- 2010-06-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lamotrigine | Small molecule | 25 mg | Oral |
| Subject | Lamotrigine | Small molecule | 100 mg | Oral |
| Subject | Lamotrigine | Small molecule | 150 mg | Oral |
| Subject | Lamotrigine | Small molecule | 175 mg | Oral |
| Subject | Vofopitant | Small molecule | 5 mg | Oral |
| Subject | Vofopitant | Small molecule | 10 mg | Oral |