drugset / Trial / NCT00909519
Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of Furosemide
RandomizedParallel-groupQuadruple-blindBasic science
Summary
This phase 1 study is an 8-day treatment period, randomized, controlled, double-blind, 3 parallel-groups, monocentric study. The primary objective is to evaluate the effect of naproxcinod on the renal function when co-administered with furosemide in comparison to naproxen and placebo.
Timeline
- Start
- 2009-01
- Primary completion
- 2009-04
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Naproxen | Small molecule | 500 mg | — |
| Subject | naproxcinod | Other / unclassified | 750 mg | — |
| Background | Furosemide | Other / unclassified | 40 mg | Intravenous |
Indications
No indication recorded.