Effect of Add-on Montelukast to Inhaled Corticosteroids on Airway Responsiveness

Summary

Leukotriene receptor antagonists appear to posses additive anti-inflammatory effects to the effect of inhaled corticosteroids. Hypothesis: Treatment with oral montelukast will lower the dose-response plateau to inhaled methacholine in patients with mild to moderate persistent asthma treated with a stable dose of inhaled corticosteroids.

Timeline

Start

2002-08

Primary completion

2006-05

Completion

2006-10

Drugs

Indications