Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy

Phase 2 Completed 33 enrolled Thomas Gardner Juvenile Diabetes Research Foundation · collab Penn State University · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This 24 month randomized research study will evaluate whether doxycycline can slow the deterioration or improve retinal function among patients with mild to moderate non-proliferative diabetic retinopathy.

Timeline

Start: 2009-07
Primary completion: 2012-07
Completion: 2012-07

Publications

Scott IU, Jackson GR, Quillen DA, Klein R, Liao J, Gardner TW. Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in mild to moderate nonproliferative diabetic retinopathy: a randomized proof-of-concept clinical trial. JAMA Ophthalmol. 2014 Sep;132(9):1137-42. doi: 10.1001/jamaophthalmol.2014.1422.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Doxycycline	Small molecule	50 mg	Oral

Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy

Summary

Timeline

Publications

Drugs

Indications