A Drug Interaction Study of SPD503 and Vyvanse Administered Alone and In Combination in Normal Healthy Volunteers

NCT00919867 ↗

Phase 1 Completed 42 enrolled Shire

RandomizedCrossoverOpen-labelOther

Summary

Drug-drug interaction study; to examine the pharmacokinetics of SPD503 and VYVANSE (lisdexamfetamine dimesylate) when given alone, and in combination.

Timeline

Start: 2009-06-24
Primary completion: 2009-07-30
Completion: 2009-07-30

Publications

Results Roesch B, Corcoran ME, Fetterolf J, Haffey M, Martin P, Preston P, Purkayastha J, Wang P, Ermer J. Pharmacokinetics of coadministered guanfacine extended release and lisdexamfetamine dimesylate. Drugs R D. 2013 Jun;13(2):119-28. doi: 10.1007/s40268-013-0014-8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Guanfacine	Small molecule	4 mg	Oral
Comparator	Lisdexamfetamine Dimesylate	Small molecule	50 mg	Oral

Indications

No indication recorded.