Safety of VAX102 Vaccine Given With Seasonal Flu Vaccine in Healthy Adults

Summary

The study will assess the safety, reactogenicity, and tolerability of VAX102 when given with Trivalent Inactivated Influenza Vaccine (TIV) delivered in the same arm as two separate IM injections in healthy adults 18 to 49 years. The investigators will measure the immunogenicity of the VAX102 when given with TIV and the antibody response to TIV when given with VAX102 compared to TIV alone.

Timeline

Start

2009-06

Primary completion

2009-07

Completion

2009-09

Publications

• Talbot HK, Rock MT, Johnson C, Tussey L, Kavita U, Shanker A, Shaw AR, Taylor DN. Immunopotentiation of trivalent influenza vaccine when given with VAX102, a recombinant influenza M2e vaccine fused to the TLR5 ligand flagellin. PLoS One. 2010 Dec 28;5(12):e14442. doi: 10.1371/journal.pone.0014442.

Drugs

Indications