Varenicline and Bupropion for Smoking Cessation

Phase 2/3 Completed 506 enrolled Mayo Clinic National Cancer Institute (NCI) · collab University of Minnesota · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study provides an opportunity to combine varenicline and bupropion SR and capitalize on the potential additive benefit. The investigators hypothesize that this will further increase long-term (≥ 6 months) smoking abstinence rates.

Timeline

Start: 2009-09
Primary completion: 2013-04
Completion: 2013-04

Publications

Results Ebbert JO, Hatsukami DK, Croghan IT, Schroeder DR, Allen SS, Hays JT, Hurt RD. Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. JAMA. 2014 Jan 8;311(2):155-63. doi: 10.1001/jama.2013.283185.
Livingstone-Banks J, Fanshawe TR, Thomas KH, Theodoulou A, Hajizadeh A, Hartman L, Lindson N. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 May 5;5(5):CD006103. doi: 10.1002/14651858.CD006103.pub8.
Hartmann-Boyce J, Theodoulou A, Farley A, Hajek P, Lycett D, Jones LL, Kudlek L, Heath L, Hajizadeh A, Schenkels M, Aveyard P. Interventions for preventing weight gain after smoking cessation. Cochrane Database Syst Rev. 2021 Oct 6;10(10):CD006219. doi: 10.1002/14651858.CD006219.pub4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupropion	Small molecule	150 mg	—
Comparator	Varenicline	Small molecule	1 mg	—

Indications

No indication recorded.