Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

Phase 2/3 Completed 52 enrolled Mayo Clinic

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Smokeless tobacco use ("chewing") is associated with negative health effects. To date, no medications have been shown to help chewers quit long-term. High dose nicotine patch therapy may improve the chances that chewers can quit for good. If found to be effective, chewers may use this treatment to help them quit and reduce their risk for negative health effects.

Timeline

Start: 2010-07
Primary completion: 2013-06
Completion: 2013-06

Publications

Results Ebbert JO, Croghan IT, Schroeder DR, Hurt RD. A randomized phase II clinical trial of high-dose nicotine patch therapy for smokeless tobacco users. Nicotine Tob Res. 2013 Dec;15(12):2037-44. doi: 10.1093/ntr/ntt097. Epub 2013 Jul 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nicotine	Unknown	42 mg	Other

Indications

No indication recorded.