drugset / Trial / NCT00939588
Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients
RandomizedParallel-groupTriple-blindBasic science
Summary
This study is designed as a mechanistic study to compare the effect of two different combinations of anti-hypertensive treatments (aliskiren and valsartan vs. telmisartan and ramipril) on the renin-angiotensin-aldosterone system (RAAS) in patients with moderate hypertension.
Timeline
- Start
- 2009-07
- Primary completion
- 2009-12
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aliskiren | Small molecule | 300 mg | — |
| Comparator | Ramipril | Small molecule | 10 mg | — |
| Comparator | Telmisartan | Other / unclassified | 80 mg | — |
| Subject | Valsartan | Unknown | 320 mg | — |