A Study Of Kappa Opioid Receptor Occupancy Of PF-04455242, Using PET (Positron Emission Tomography)

Summary

This is a subject blind, investigator and sponsor open, randomized study consisting of 2 parts. Up to 15 healthy subjects will be included in the study. In the first part of the study the test retest reliability of the radiotracer \[11C\] PF 04767135 binding in man will be assessed. In the second part of this study, using \[11C\] PF 04767135, kappa opioid receptor occupancy (RO) will be assessed in up to three cohorts of subjects.

Timeline

Start

2009-09

Primary completion

2009-12

Completion

2009-12

Outcome

Outcome not reported

Stopped: “This study was terminated on January 6, 2010, due to toxicology findings in animals exposed to PF-04455242 for three months.”

Drugs

Indications