Folate Absorption Across the Large Intestine

Phase 1 Completed 9 enrolled The Hospital for Sick Children Centers for Disease Control and Prevention · collab University of Florida · collab

NaSingle-groupOpen-labelTreatment

Summary

The objective of this study is to determine whether the intact human colon with an unaltered microflora distribution absorbs folate and to what extent it is absorbed into the systemic circulation using a dual/oral intravenous route. This will elicit an understanding of colonic folate absorption and metabolism.

Timeline

Start: 2008-09
Primary completion: 2009-03
Completion: 2009-03

Publications

Lakoff A, Fazili Z, Aufreiter S, Pfeiffer CM, Connolly B, Gregory JF 3rd, Pencharz PB, O'Connor DL. Folate is absorbed across the human colon: evidence by using enteric-coated caplets containing 13C-labeled [6S]-5-formyltetrahydrofolate. Am J Clin Nutr. 2014 Nov;100(5):1278-86. doi: 10.3945/ajcn.114.091785. Epub 2014 Sep 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	13C5-Calcium-L-Leucovorin	Unknown	100 ug	Oral
Comparator	13C5-Calcium-L-Leucovorin	Unknown	400 ug	Oral

Indications

No indication recorded.