Homeopathic Medication and Nutritional Oriented Diet to Treat Overweight Pregnant Women With Mental Disorder

Summary

The purpose of this study is to evaluate the efficacy of homeopathic treatment in pregnant women with overweight and class I obesity with suspicion of a mental disorder.

Timeline

Start

2009-08

Primary completion

2012-12

Completion

2012-12

Publications

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• Background Monteiro CA, Conde WL, Popkin BM. Is obesity replacing or adding to undernutrition? Evidence from different social classes in Brazil. Public Health Nutr. 2002 Feb;5(1A):105-12. doi: 10.1079/PHN2001281.
• Background Yang D, Fontaine KR, Wang C, Allison DB. Weight loss causes increased mortality: cons. Obes Rev. 2003 Feb;4(1):9-16. doi: 10.1046/j.1467-789x.2003.00092.x.
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• Background Frankel PH. Obesity and cancer. N Engl J Med. 2003 Jul 31;349(5):502-4; author reply 502-4. No abstract available.
• Background Allison DB, Saunders SE. Obesity in North America. An overview. Med Clin North Am. 2000 Mar;84(2):305-32, v. doi: 10.1016/s0025-7125(05)70223-6.
• Background Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA. 1999 Oct 27;282(16):1530-8. doi: 10.1001/jama.282.16.1530.
• Background Harris T, Cook EF, Garrison R, Higgins M, Kannel W, Goldman L. Body mass index and mortality among nonsmoking older persons. The Framingham Heart Study. JAMA. 1988 Mar 11;259(10):1520-4.
• Background Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, Dietz PM. Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care. 2007 Aug;30(8):2070-6. doi: 10.2337/dc06-2559a. Epub 2007 Apr 6.
• Background Ohlin A, Rossner S. Maternal body weight development after pregnancy. Int J Obes. 1990 Feb;14(2):159-73.
• Background Greene GW, Smiciklas-Wright H, Scholl TO, Karp RJ. Postpartum weight change: how much of the weight gained in pregnancy will be lost after delivery? Obstet Gynecol. 1988 May;71(5):701-7.
• Background Linne Y, Barkeling B, Rossner S. Long-term weight development after pregnancy. Obes Rev. 2002 May;3(2):75-83. doi: 10.1046/j.1467-789x.2002.00061.x.
• Background Gore SA, Brown DM, West DS. The role of postpartum weight retention in obesity among women: a review of the evidence. Ann Behav Med. 2003 Oct;26(2):149-59. doi: 10.1207/S15324796ABM2602_07.
• Background Lederman SA. Pregnancy weight gain and postpartum loss: avoiding obesity while optimizing the growth and development of the fetus. J Am Med Womens Assoc (1972). 2001 Spring;56(2):53-8.
• Background Boardley DJ, Sargent RG, Coker AL, Hussey JR, Sharpe PA. The relationship between diet, activity, and other factors, and postpartum weight change by race. Obstet Gynecol. 1995 Nov;86(5):834-8. doi: 10.1016/0029-7844(95)00283-W.
• Background Parker JD, Abrams B. Differences in postpartum weight retention between black and white mothers. Obstet Gynecol. 1993 May;81(5 ( Pt 1)):768-74.
• Background Potter S, Hannum S, McFarlin B, Essex-Sorlie D, Campbell E, Trupin S. Does infant feeding method influence maternal postpartum weight loss? J Am Diet Assoc. 1991 Apr;91(4):441-6.
• Background Scholl TO, Hediger ML, Schall JI, Ances IG, Smith WK. Gestational weight gain, pregnancy outcome, and postpartum weight retention. Obstet Gynecol. 1995 Sep;86(3):423-7. doi: 10.1016/0029-7844(95)00190-3.
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• Background Maddi SR, Khoshaba DM, Persico M, Bleecker F, VanArsdall G. Psychosocial correlates of psychopathology in a national sample of the morbidly obese. Obes Surg. 1997 Oct;7(5):397-404. doi: 10.1381/096089297765555377.
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• Background Pop-Jordanova N. Psychological characteristics and biofeedback mitigation in preadolescents with eating disorders. Pediatr Int. 2000 Feb;42(1):76-81. doi: 10.1046/j.1442-200x.2000.01176.x.
• Background Coggon D, Martyn C, Palmer KT, Evanoff B. Assessing case definitions in the absence of a diagnostic gold standard. Int J Epidemiol. 2005 Aug;34(4):949-52. doi: 10.1093/ije/dyi012.
• Background Botega NJ, Bio MR, Zomignani MA, Garcia C Jr, Pereira WA. [Mood disorders among inpatients in ambulatory and validation of the anxiety and depression scale HAD]. Rev Saude Publica. 1995 Oct;29(5):355-63. doi: 10.1590/s0034-89101995000500004. Portuguese.
• Background Kessler RC, Molnar BE, Feurer ID, Appelbaum M. Patterns and mental health predictors of domestic violence in the United States: results from the National Comorbidity Survey. Int J Law Psychiatry. 2001 Jul-Oct;24(4-5):487-508. doi: 10.1016/s0160-2527(01)00080-2. No abstract available.
• Background Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Arch Gen Psychiatry. 1992 Sep;49(9):716-22. doi: 10.1001/archpsyc.1992.01820090044008.
• Background Pine DS, Cohen P, Gurley D, Brook J, Ma Y. The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry. 1998 Jan;55(1):56-64. doi: 10.1001/archpsyc.55.1.56.
• Background Wittchen HU, Stein MB, Kessler RC. Social fears and social phobia in a community sample of adolescents and young adults: prevalence, risk factors and co-morbidity. Psychol Med. 1999 Mar;29(2):309-23. doi: 10.1017/s0033291798008174.
• Background McCarter-Spaulding DE. Medications in pregnancy and lactation. MCN Am J Matern Child Nurs. 2005 Jan-Feb;30(1):10-7; quiz 18-9.
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• Background Endler PC, Pongratz W, Smith CW, Schulte J. Non-molecular information transfer from thyroxine to frogs with regard to homeopathic toxicology. Vet Hum Toxicol. 1995 Jun;37(3):259-60. No abstract available.
• Background Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol. 2006 Fall;13(3):e268-76. Epub 2006 Nov 3.
• Background McKenna L, McIntyre M. What over-the-counter preparations are pregnant women taking? A literature review. J Adv Nurs. 2006 Dec;56(6):636-45. doi: 10.1111/j.1365-2648.2006.04037.x.
• Background Field T. Pregnancy and labor alternative therapy research. Altern Ther Health Med. 2008 Sep-Oct;14(5):28-34.
• Background Dayan J, Yoshida K. [Psychological and pharmacological treatments of mood and anxiety disorders during pregnancy and postpartum. Review and synthesis]. J Gynecol Obstet Biol Reprod (Paris). 2007 Oct;36(6):530-48. doi: 10.1016/j.jgyn.2007.06.004. Epub 2007 Jul 5. French.
• Background Charlton RA, Cunnington MC, de Vries CS, Weil JG. Data resources for investigating drug exposure during pregnancy and associated outcomes: the General Practice Research Database (GPRD) as an alternative to pregnancy registries. Drug Saf. 2008;31(1):39-51. doi: 10.2165/00002018-200831010-00004.
• Background Kyle PM. Drugs and the fetus. Curr Opin Obstet Gynecol. 2006 Apr;18(2):93-9. doi: 10.1097/01.gco.0000192974.61729.4c.
• Background Guelinckx I, Devlieger R, Beckers K, Vansant G. Maternal obesity: pregnancy complications, gestational weight gain and nutrition. Obes Rev. 2008 Mar;9(2):140-50. doi: 10.1111/j.1467-789X.2007.00464.x. Epub 2008 Jan 21.
• Background Polley BA, Wing RR, Sims CJ. Randomized controlled trial to prevent excessive weight gain in pregnant women. Int J Obes Relat Metab Disord. 2002 Nov;26(11):1494-502. doi: 10.1038/sj.ijo.0802130.
• Background Pearlstein T. Perinatal depression: treatment options and dilemmas. J Psychiatry Neurosci. 2008 Jul;33(4):302-18.
• Background Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004 Nov;49(11):726-35. doi: 10.1177/070674370404901103.
• Background Epstein LH, Wing RR, Penner BC, Kress MJ. Effect of diet and controlled exercise on weight loss in obese children. J Pediatr. 1985 Sep;107(3):358-61. doi: 10.1016/s0022-3476(85)80506-0.
• Background Harding TW, de Arango MV, Baltazar J, Climent CE, Ibrahim HH, Ladrido-Ignacio L, Murthy RS, Wig NN. Mental disorders in primary health care: a study of their frequency and diagnosis in four developing countries. Psychol Med. 1980 May;10(2):231-41. doi: 10.1017/s0033291700043993.
• Background Mari JJ, Williams P. A comparison of the validity of two psychiatric screening questionnaires (GHQ-12 and SRQ-20) in Brazil, using Relative Operating Characteristic (ROC) analysis. Psychol Med. 1985 Aug;15(3):651-9. doi: 10.1017/s0033291700031500.
• Background Mari JJ, Williams P. A validity study of a psychiatric screening questionnaire (SRQ-20) in primary care in the city of Sao Paulo. Br J Psychiatry. 1986 Jan;148:23-6. doi: 10.1192/bjp.148.1.23.
• Background Milgrom LR. Vitalism, complexity and the concept of spin. Homeopathy. 2002 Jan;91(1):26-31. doi: 10.1054/homp.2001.0013.
• Background Milgrom LR. Patient-practitioner-remedy (PPR) entanglement. Part 3. Refining the quantum metaphor for homeopathy. Homeopathy. 2003 Jul;92(3):152-60. doi: 10.1016/s1475-4916(03)00038-9.
• Background Teixeira MZ. Homeopathic use of modern medicines: utilisation of the curative rebound effect. Med Hypotheses. 2003 Feb;60(2):276-83. doi: 10.1016/s0306-9877(02)00386-9.
• Background Weingartner O. What is the therapeutically active ingredient of homeopathic potencies? Homeopathy. 2003 Jul;92(3):145-51. doi: 10.1016/s1475-4916(03)00037-7.
• Background Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, Jonas WB. Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet. 1997 Sep 20;350(9081):834-43. doi: 10.1016/s0140-6736(97)02293-9.
• Background Shang A, Huwiler-Muntener K, Nartey L, Juni P, Dorig S, Sterne JA, Pewsner D, Egger M. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet. 2005 Aug 27-Sep 2;366(9487):726-32. doi: 10.1016/S0140-6736(05)67177-2.
• Background Oberbaum M, Singer SR, Frass M. Homeopathic research after the Lancet meta analysis--a moment for introspection. Complement Ther Med. 2005 Dec;13(4):303-5. doi: 10.1016/j.ctim.2005.10.006. Epub 2005 Nov 17. No abstract available.
• Background Mathie RT. The research evidence base for homeopathy: a fresh assessment of the literature. Homeopathy. 2003 Apr;92(2):84-91. doi: 10.1016/s1475-4916(03)00006-7.
• Background Jonas WB, Kaptchuk TJ, Linde K. A critical overview of homeopathy. Ann Intern Med. 2003 Mar 4;138(5):393-9. doi: 10.7326/0003-4819-138-5-200303040-00009.
• Background White A, Slade P, Hunt C, Hart A, Ernst E. Individualised homeopathy as an adjunct in the treatment of childhood asthma: a randomised placebo controlled trial. Thorax. 2003 Apr;58(4):317-21. doi: 10.1136/thorax.58.4.317.
• Background Jacobs J, Springer DA, Crothers D. Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trial. Pediatr Infect Dis J. 2001 Feb;20(2):177-83. doi: 10.1097/00006454-200102000-00012.
• Background Frei H, Thurneysen A. Homeopathy in acute otitis media in children: treatment effect or spontaneous resolution? Br Homeopath J. 2001 Oct;90(4):180-2. doi: 10.1054/homp.1999.0505.
• Background Taylor MA, Reilly D, Llewellyn-Jones RH, McSharry C, Aitchison TC. Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. BMJ. 2000 Aug 19-26;321(7259):471-6. doi: 10.1136/bmj.321.7259.471.
• Background Jacobs J, Jonas WB, Jimenez-Perez M, Crothers D. Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials. Pediatr Infect Dis J. 2003 Mar;22(3):229-34. doi: 10.1097/01.inf.0000055096.25724.48.
• Background Frass M, Linkesch M, Banyai S, Resch G, Dielacher C, Lobl T, Endler C, Haidvogl M, Muchitsch I, Schuster E. Adjunctive homeopathic treatment in patients with severe sepsis: a randomized, double-blind, placebo-controlled trial in an intensive care unit. Homeopathy. 2005 Apr;94(2):75-80. doi: 10.1016/j.homp.2005.01.002.
• Background Olson CM. Achieving a healthy weight gain during pregnancy. Annu Rev Nutr. 2008;28:411-23. doi: 10.1146/annurev.nutr.28.061807.155322.
• Background Kiel DW, Dodson EA, Artal R, Boehmer TK, Leet TL. Gestational weight gain and pregnancy outcomes in obese women: how much is enough? Obstet Gynecol. 2007 Oct;110(4):752-8. doi: 10.1097/01.AOG.0000278819.17190.87.
• Background Idler EL, Benyamini Y. Self-rated health and mortality: a review of twenty-seven community studies. J Health Soc Behav. 1997 Mar;38(1):21-37.

Drugs

Indications