Study of the Effects of Iron Levels on the Lungs at High Altitude

Completed 33 enrolled University of Oxford Universidad Peruana Cayetano Heredia · collab

RandomizedCrossoverQuadruple-blindBasic science

Summary

The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels. The purpose of this study is to determine whether this is true at high altitude, where oxygen levels are low.

Timeline

Start: 2008-10
Primary completion: 2008-11
Completion: 2008-11

Outcome

Mixed primary results

paper from 37 mm Hg (95% CI, 34-40 mm Hg) to 31 mm Hg (95% CI, 29-33 mm Hg; P = .01). PMID 19809026 ↗

paper During the subsequent crossover period, no acute effect of iron replacement on PASP was detected. PMID 19809026 ↗

Publications

Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, Leon-Velarde F, Robbins PA. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA. 2009 Oct 7;302(13):1444-50. doi: 10.1001/jama.2009.1404.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Iron sucrose	Unknown	200 mg	Intravenous