A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment Versus Golytely for Bowel Cleansing Prior to Colonoscopy

Phase 4 Completed 425 enrolled Brooke Army Medical Center

RandomizedParallel-groupSingle-blindTreatment

Summary

Miralax (PEG 3350) has been shown to be a safe and uncomplicated bowel preparation prior to colonoscopy in pediatric populations. This study seeks to confirm the efficacy of this bowel cleansing regimen in adults and to determine the benefit of adding a pretreatment medication to this bowel preparation. The tolerability of Miralax will hopefully improve patient satisfaction with colonoscopy and decrease their reluctance to be screened because of the uncomfortable taste and side effects of bowel preparation regimens.

Timeline

Start: 2009-07
Primary completion: 2010-05
Completion: 2010-05

Publications

Hjelkrem M, Stengel J, Liu M, Jones DP, Harrison SA. MiraLAX is not as effective as GoLytely in bowel cleansing before screening colonoscopies. Clin Gastroenterol Hepatol. 2011 Apr;9(4):326-332.e1. doi: 10.1016/j.cgh.2010.11.007. Epub 2010 Nov 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bisacodyl	Small molecule	10 mg	Oral
Comparator	Lubiprostone	Small molecule	24 ug	Oral
Comparator	polyethylene glycol	Other / unclassified	1 unknown	Oral
Comparator	polyethylene glycol	Other / unclassified	255 g	Oral

Indications

No indication recorded.