Lubiprostone, Colonic Motility and Sensation

Phase 4 Completed 60 enrolled Mayo Clinic National Center for Research Resources (NCRR) · collab National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab Takeda · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

This study is being done to evaluate the effects of lubiprostone, a drug approved and used for constipation, on pattern of contractions of the colon and the colon's sensitivity to distension.

Timeline

Start: 2007-09
Primary completion: 2008-07
Completion: 2009-07

Publications

Background Sweetser S, Busciglio IA, Camilleri M, Bharucha AE, Szarka LA, Papathanasopoulos A, Burton DD, Eckert DJ, Zinsmeister AR. Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G295-301. doi: 10.1152/ajpgi.90558.2008. Epub 2008 Nov 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Lubiprostone	Small molecule	24 ug	Oral

Indications

No indication recorded.