drugset / Trial / NCT00953849

Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity

NCT00953849

Phase 1/2 Completed 21 enrolled VA Office of Research and Development
RandomizedParallel-groupOpen-labelBasic science

Summary

The poor survival of Veterans with oral cancer underscores the significance of identifying new treatment approaches. The proposed studies will test a new 2 pronged immunotherapeutic approach for oral cancer patients which lessen the immune inhibitory environment while maturing cells that can stimulate T cell reactivity against oral cancer cells.

Timeline

Start
2009-11
Primary completion
2015-12
Completion
2015-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Calcitriol Small molecule 4 ug Other
Subject Celecoxib Other / unclassified 400 mg

Indications