Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients

Completed 40 enrolled Hospital de Clinicas de Porto Alegre

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of the study is to determine if pyridostigmine bromide improves heart rate variability of type 2 diabetes mellitus subjects with cardiovascular autonomic neuropathy.

Timeline

Start: 2005-03
Primary completion: 2009-07
Completion: 2010-05

Publications

Background Behling A, Moraes RS, Rohde LE, Ferlin EL, Nobrega AC, Ribeiro JP. Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure. Am Heart J. 2003 Sep;146(3):494-500. doi: 10.1016/S0002-8703(03)00319-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pyridostigmine	Small molecule	30 mg	Oral

Indications

No indication recorded.