Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation

Phase 1/2 Completed 4 enrolled The New York Eye & Ear Infirmary

NaSingle-groupOpen-labelTreatment

Summary

Autologous platelet rich fibrin matrix will release growth factors which could increase the production of dermal proteins or affect the vascularity and status of neighboring tissues. This study is designed to evaluate the histologic and biochemical effect of injection of platelet rich fibrin matrix into the skin.

Timeline

Start: 2009-10
Primary completion: 2011-02
Completion: 2011-07

Publications

Results Sclafani AP, McCormick SA. Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg. 2012 Mar-Apr;14(2):132-6. doi: 10.1001/archfacial.2011.784. Epub 2011 Oct 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Platelet rich fibrin matrix	Unknown	—	Other

Indications

No indication recorded.