Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety

Summary

The purpose of this study is to investigate the utility of Yohimbine hydrochloride for facilitating fear extinction in a sample of patients with social phobia who will be treated with CBT.

Timeline

Start

2009-03

Primary completion

2013-01

Completion

2013-01

Outcome

Met primary endpoint

registry analysis (superiority or other test); Sugar Pill vs Yohimbine Hydrochloride; p = .015; Slope 10.46; Regression, Linear NCT00958880 ↗

Publications

• Background Powers MB, Smits JA, Otto MW, Sanders C, Emmelkamp PM. Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation. J Anxiety Disord. 2009 Apr;23(3):350-6. doi: 10.1016/j.janxdis.2009.01.001. Epub 2009 Jan 15.
• Smits JA, Rosenfield D, Davis ML, Julian K, Handelsman PR, Otto MW, Tuerk P, Shiekh M, Rosenfield B, Hofmann SG, Powers MB. Yohimbine enhancement of exposure therapy for social anxiety disorder: a randomized controlled trial. Biol Psychiatry. 2014 Jun 1;75(11):840-6. doi: 10.1016/j.biopsych.2013.10.008. Epub 2013 Oct 16.

Drugs

Indications