A Study Investigating the Effect of Montelukast in Patients With Seasonal Allergic Rhinitis (MK-0476-192)(COMPLETED)

Phase 3 Completed 829 enrolled Organon and Co

RandomizedParallel-groupDouble-blindTreatment

Summary

A study of the ability of montelukast to improve signs and symptoms of seasonal allergic rhinitis compared with placebo. Loratadine is included in the study as an active control.

Timeline

Start: 2000-08
Primary completion: 2000-10
Completion: 2000-11

Outcome

Met primary endpoint

paper Montelukast significantly improved daytime nasal symptoms score and individual scores of congestion, rhinorrhea, itching, and sneezing compared with placebo. PMID 15049402 ↗

Publications

Results Chervinsky P, Philip G, Malice MP, Bardelas J, Nayak A, Marchal JL, van Adelsberg J, Bousquet J, Tozzi CA, Reiss TF. Montelukast for treating fall allergic rhinitis: effect of pollen exposure in 3 studies. Ann Allergy Asthma Immunol. 2004 Mar;92(3):367-73. doi: 10.1016/S1081-1206(10)61576-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Loratadine	Small molecule	10 mg	Oral
Subject	Montelukast	Other / unclassified	10 mg	Oral