Study of Meningococcal B Vaccine and ACWY Conjugate Vaccine in Healthy Adults

Summary

The study involves the measurement of immune response to vaccination with three doses of a meningococcal B vaccine and a single dose of a meningococcal ACYW conjugate vaccine in healthy adults (Laboratory workers). The study will be completed at the Manchester Medical Microbiology Partnership in the UK and will enrol staff who may be at potential occupational exposure to meningococci. Blood samples will be taken before and after each vaccination and used to determine if the vaccines induce protective responses.

Timeline

Start

2010-07

Primary completion

2011-03

Completion

2012-03

Publications

• Background Findlow J, Bai X, Findlow H, Newton E, Kaczmarski E, Miller E, Borrow R. Safety and immunogenicity of a four-component meningococcal group B vaccine (4CMenB) and a quadrivalent meningococcal group ACWY conjugate vaccine administered concomitantly in healthy laboratory workers. Vaccine. 2015 Jun 26;33(29):3322-30. doi: 10.1016/j.vaccine.2015.05.027. Epub 2015 May 27.
• Ramirez-Bencomo F, Thistlethwaite A, Viviani V, Bartolini E, Pizza M, Biolchi A, Muzzi A, Delany I, Awanye AM, Chang CM, Borrow R, Derrick JP. Identification of immunogenic outer membrane vesicle vaccine antigen components using a meningococcal protein microarray. Vaccine. 2025 Apr 19;53:126953. doi: 10.1016/j.vaccine.2025.126953. Epub 2025 Mar 4.

Drugs

Indications