drugset / Trial / NCT00965289
High-dose Chemotherapy With Rituximab for Adults With Aggressive Large B-cell Lymphoma
Phase 2
Completed
42 enrolled
Nantes University Hospital
French Innovative Leukemia Organisation · collabHoffmann-La Roche · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
A prospective pilot trial was proposed to patients with DLBCL, with IH or high adjusted IPI, up to the age of 60 y.o. This program consisted of 2 courses of high-dose R-CHOP-like regimen, followed by a course of high-dose methotrexate with cytarabin. For patients who achieved at least a PR, ASCT started with a BEAM regimen.
Timeline
- Start
- 2002-04
- Primary completion
- 2003-05
- Completion
- 2009-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Rituximab | Monoclonal antibody | 375 mg/m2 | Other |