Pharmacokinetics and Pharmacodynamics of Sertraline After Low Dose Administration

Phase 4 Completed 10 enrolled Seoul National University Hospital Korea National Enterprise for Clinical Trials · collab Ministry of Health, Welfare and Family Affairs · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study aimed to explore the pharmacokinetics and pharmacodynamics of low dose sertraline with \[11C\] sertraline positron emission tomography (PET) study.

Timeline

Start: 2009-07
Primary completion: 2009-08
Completion: 2010-03

Publications

Shin KH, Kim KP, Lim KS, Kim JW, Lee YS, Yang BY, Lee JS, Jung JM, Yoon SH, Jang IJ, Yu KS. A positron emission tomography microdosing study with sertraline in healthy volunteers. Int J Clin Pharmacol Ther. 2012 Mar;50(3):224-32. doi: 10.5414/cp201644.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sertraline	Small molecule	5 mg	—
Subject	Sertraline	Small molecule	25 mg	—
Subject	Sertraline	Small molecule	50 mg	—

Indications

No indication recorded.