Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin

Phase 1 Completed 20 enrolled Liu Hua Qiao Hospital Guangdong Province, Department of Science and Technology · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

The aim of the study is to investigate the effects of CYP3A polymorphisms on the pharmacokinetics of Atorvastatin in Chinese subjects with coronary heart disease.

Timeline

Start: 2009-06
Primary completion: 2010-12
Completion: 2011-03

Publications

He BX, Shi L, Qiu J, Zeng XH, Zhao SJ. The effect of CYP3A4*1G allele on the pharmacokinetics of atorvastatin in Chinese Han patients with coronary heart disease. J Clin Pharmacol. 2014 Apr;54(4):462-7. doi: 10.1002/jcph.229. Epub 2013 Nov 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Atorvastatin	Small molecule	20 mg	Oral

Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin

Summary

Timeline

Publications

Drugs

Indications