Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After Percutaneous Coronary Intervention (PCI)

Terminated 60 enrolled Indiana University National Center for Research Resources (NCRR) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This research study plans to evaluate the use of atorvastatin in patients with coronary artery disease given immediately before PCI and whether it will decrease the amount of heart damage after PCI.

Timeline

Start: 2008-11
Primary completion: 2014-06
Completion: 2014-08

Outcome

Missed primary endpoint

Stopped (Enrollment): “Slower than anticipated enrollment for pilot study.”

registry analysis (superiority or other test); No Atorvastatin vs Atorvastatin; p = 0.97; Chi-squared NCT00979940 ↗

Publications

Kreutz RP, Breall JA, Sinha A, von der Lohe E, Kovacs RJ, Flockhart DA. Simultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention. Clin Pharmacol. 2016 Jun 3;8:45-50. doi: 10.2147/CPAA.S98790. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	80 mg	Oral