Weekly Dosing of Malarone ® for Prevention of Malaria

Phase 2 Completed 35 enrolled U.S. Army Medical Research and Development Command

RandomizedParallel-groupTriple-blindPrevention

Summary

The purpose of this study is to determine whether Malarone ®, which is a drug approved to prevent malaria when taken daily, will still effectively prevent malaria if taken weekly.

Timeline

Start: 2009-09
Primary completion: 2010-04
Completion: 2010-04

Publications

Results Deye GA, Miller RS, Miller L, Salas CJ, Tosh D, Macareo L, Smith BL, Fracisco S, Clemens EG, Murphy J, Sousa JC, Dumler JS, Magill AJ. Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model. Clin Infect Dis. 2012 Jan 15;54(2):232-9. doi: 10.1093/cid/cir770. Epub 2011 Nov 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atovaquone	Small molecule	250 mg	—
Subject	Atovaquone	Small molecule	500 mg	—
Subject	Atovaquone	Small molecule	1000 mg	—
Subject	Proguanil	Small molecule	100 mg	—
Subject	Proguanil	Small molecule	200 mg	—
Subject	Proguanil	Small molecule	400 mg	—

Weekly Dosing of Malarone ® for Prevention of Malaria

Summary

Timeline

Publications

Drugs

Indications