Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043

Phase 1 Completed 72 enrolled AstraZeneca

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The primary purpose of this study is to assess the safety and tolerability of AZD3043 following administration of single ascending bolus doses (Part A) and single ascending bolus doses followed by infusion (Part B).

Timeline

Start: 2009-09
Primary completion: —
Completion: 2009-12

Publications

Norberg A, Koch P, Kanes SJ, Bjornsson MA, Barassin S, Ahlen K, Kalman S. A Bolus and Bolus Followed by Infusion Study of AZD3043, an Investigational Intravenous Drug for Sedation and Anesthesia: Safety and Pharmacodynamics in Healthy Male and Female Volunteers. Anesth Analg. 2015 Oct;121(4):894-903. doi: 10.1213/ANE.0000000000000804.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	AZD3043	Small molecule	1 mg/kg	Intravenous
Subject	AZD3043	Small molecule	1.5 mg/kg	Intravenous
Subject	AZD3043	Small molecule	2 mg/kg	Intravenous
Subject	AZD3043	Small molecule	4 mg/kg	Intravenous
Subject	AZD3043	Small molecule	6 mg/kg	Intravenous
Subject	AZD3043	Small molecule	10 mg/kg	Intravenous
Subject	AZD3043	Small molecule	15 mg/kg	Intravenous
Subject	AZD3043	Small molecule	30 mg/kg	Intravenous
Subject	AZD3043	Small molecule	40 mg/kg	Intravenous

Indications

No indication recorded.