Pharmacological Postconditioning During the Aortic Valvular Surgery

Phase 3 Completed 56 enrolled Hospices Civils de Lyon

RandomizedParallel-groupSingle-blindTreatment

Summary

Primary objective: To evaluate the efficacy of the cyclosporin A administration to induce a cardioprotection during the valvular surgery.

Timeline

Start: 2008-10
Primary completion: 2010-09
Completion: 2010-09

Outcome

Met primary endpoint

paper A significant 35% reduction of area under the curve for cardiac troponin I was observed in the cyclosporine group compared with the control group PMID 25050491 ↗

Publications

Results Chiari P, Angoulvant D, Mewton N, Desebbe O, Obadia JF, Robin J, Farhat F, Jegaden O, Bastien O, Lehot JJ, Ovize M. Cyclosporine protects the heart during aortic valve surgery. Anesthesiology. 2014 Aug;121(2):232-8. doi: 10.1097/ALN.0000000000000331.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cyclosporine	Peptide	2.5 mg/kg	Intravenous