drugset / Trial / NCT00989027
Impact of Uterotonic Agents on Isolated Human Myometrium
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs. The drugs studied are typically used to contract the uterus when a pregnant patient continues to bleed after delivery. Amongst the uterotonic drugs (used to contract the uterus), namely oxytocin, ergonovine and carboprost, the most effective one to use is not known. The investigators will be testing uterine muscle samples in the presence of these drugs at various concentrations, to see what their contractility measures over time, as compared with a control sample, in which no drugs will be applied.
Timeline
- Start
- 2007-06
- Primary completion
- 2013-08
- Completion
- 2013-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Carboprost | Unknown | 1e-09 unknown | — |
| Comparator | Carboprost | Unknown | 0.001 unknown | — |
| Comparator | Oxytocin | Peptide | 1e-09 unknown | — |
| Comparator | Oxytocin | Peptide | 0.001 unknown | — |
| Comparator | ergometrine | Unknown | 1e-09 unknown | — |
| Comparator | ergometrine | Unknown | 0.001 unknown | — |
Indications
No indication recorded.