Effects Of Eplerenone On Serum Aldesterone And Plasma Renin Activity

Phase 1 Completed 20 enrolled Viatris Inc.

RandomizedSingle-groupDouble-blindOther

Summary

To evaluate the changes in serum aldosterone and plasma renin activity on Day 0 and on Days 1 and 10 after administration of 100 mg of eplerenone daily for 10 days.

Timeline

Start: 2009-10
Primary completion: 2009-11
Completion: 2009-11

Publications

Eudy RJ, Sahasrabudhe V, Sweeney K, Tugnait M, King-Ahmad A, Near K, Loria P, Banker ME, Piotrowski DW, Boustany-Kari CM. The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism. J Transl Med. 2011 Oct 21;9:180. doi: 10.1186/1479-5876-9-180.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Eplerenone	Unknown	100 mg	—

Indications

No indication recorded.