Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil

Completed 22 enrolled Johns Hopkins University National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupTriple-blindBasic science

Summary

The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.

Timeline

Start: 2009-02
Primary completion: 2010-05
Completion: 2010-05

Publications

Results Tompkins DA, Smith MT, Bigelow GE, Moaddel R, Venkata SL, Strain EC. The effect of repeated intramuscular alfentanil injections on experimental pain and abuse liability indices in healthy males. Clin J Pain. 2014 Jan;30(1):36-45. doi: 10.1097/AJP.0b013e3182851758.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Alfentanil	Other / unclassified	15 ug/kg	Intramuscular
Comparator	Diphenhydramine	Unknown	25 mg	Intramuscular

Indications

No indication recorded.