drugset / Trial / NCT00995072
Comparative Effects of Nebivolol and Metoprolol on Female Sexual Function
Non-randomizedCrossoverQuadruple-blindTreatment
Summary
Beta-blockers (BB) are an important treatment for high blood pressure and heart disease. However beta-blockers can cause sexual dysfunction (SD) and this common side effect limits successful use of this class of medications. Sexual side effects often result in drug discontinuation, compromising therapy goals. The investigators are conducting the study to determine if nebivolol, a newer beta blocker that is selective for receptors in the heart and causes vasodilation in the body causes fewer sexual side effects, or even improves sexual function, compared with metoprolol succinate.
Timeline
- Start
- 2009-10
- Primary completion
- 2013-04
- Completion
- 2013-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metoprolol | Other / unclassified | 100 mg | — |
| Subject | Metoprolol | Other / unclassified | 200 mg | — |
| Subject | Nebivolol | Other / unclassified | 5 mg | — |
| Subject | Nebivolol | Other / unclassified | 10 mg | — |