drugset / Trial / NCT00995072

Comparative Effects of Nebivolol and Metoprolol on Female Sexual Function

NCT00995072

Completed 29 enrolled East Coast Institute for Research
Non-randomizedCrossoverQuadruple-blindTreatment

Summary

Beta-blockers (BB) are an important treatment for high blood pressure and heart disease. However beta-blockers can cause sexual dysfunction (SD) and this common side effect limits successful use of this class of medications. Sexual side effects often result in drug discontinuation, compromising therapy goals. The investigators are conducting the study to determine if nebivolol, a newer beta blocker that is selective for receptors in the heart and causes vasodilation in the body causes fewer sexual side effects, or even improves sexual function, compared with metoprolol succinate.

Timeline

Start
2009-10
Primary completion
2013-04
Completion
2013-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Metoprolol Other / unclassified 100 mg
Subject Metoprolol Other / unclassified 200 mg
Subject Nebivolol Other / unclassified 5 mg
Subject Nebivolol Other / unclassified 10 mg