Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury

Summary

RCT colloids versus cristalloids only in severe burn victims. * Trial with medicinal product

Timeline

Start

2009-11

Primary completion

2013-01

Completion

2013-01

Outcome

Missed primary endpoint

paper Three-day totals of administered resuscitation fluid (medians) were 21,190 mL in the lactated Ringer's group and 19,535 mL in the HES group (HES: -1,213 mL; P = 0.39). PMID 24365167 ↗

paper There was no evidence that early fluid resuscitation with balanced HES 130/0.4 (6%) in addition to lactated Ringer's solution would lead to a volume-sparing effect PMID 24365167 ↗

Publications

• Bechir M, Puhan MA, Fasshauer M, Schuepbach RA, Stocker R, Neff TA. Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial. Crit Care. 2013 Dec 23;17(6):R299. doi: 10.1186/cc13168.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Volulyte	Other / unclassified	6 %	—
Background	Lactated Ringer's solution	Unknown	—	—

Indications

No indication recorded.