Controlled Propofol Administration

NCT01019746 ↗

Phase 4 Completed 40 enrolled McGill University Health Centre/Research Institute of the McGill University Health Centre

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare the administration of the standard anesthetic agent (propofol) using this automatic system with the manual administration of propofol by the anesthesiologist.

Timeline

Start: 2007-08
Primary completion: 2008-05
Completion: —

Outcome

Met primary endpoint

paper In the Closed-loop group, excellent control of anesthesia occurred significantly more often (P < 0.0001) PMID 20533013 ↗

paper The closed-loop system for propofol administration showed better clinical and control system performance than manual administration of propofol. PMID 20533013 ↗

Publications

Hemmerling TM, Charabati S, Zaouter C, Minardi C, Mathieu PA. A randomized controlled trial demonstrates that a novel closed-loop propofol system performs better hypnosis control than manual administration. Can J Anaesth. 2010 Aug;57(8):725-35. doi: 10.1007/s12630-010-9335-z. Epub 2010 Jun 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	—	—

Indications

No indication recorded.