Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides

Phase 1 Completed 44 enrolled GlaxoSmithKline

RandomizedParallel-groupDouble-blindBasic science

Summary

The purpose of this study is to investigate the utility of the cantharidin-induced skin blister assay for evaluation of the anti-inflammatory effects of macrolides in healthy male volunteers.

Timeline

Start: 2009-06-04
Primary completion: 2009-11-27
Completion: 2009-11-27

Publications

Pene Dumitrescu T, Anic-Milic T, Oreskovic K, Padovan J, Brouwer KL, Zuo P, Schmith VD. Development of a population pharmacokinetic model to describe azithromycin whole-blood and plasma concentrations over time in healthy subjects. Antimicrob Agents Chemother. 2013 Jul;57(7):3194-201. doi: 10.1128/AAC.02430-12. Epub 2013 Apr 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Azithromycin	Small molecule	250 mg	Oral

Indications

No indication recorded.