drugset / Trial / NCT01027598
Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer
Phase 2
Completed
202 enrolled
SCRI Development Innovations, LLC
GlaxoSmithKline · collabOSI Pharmaceuticals · collab
RandomizedSingle-groupQuadruple-blindTreatment
Summary
This randomized, placebo-controlled, Phase II trial will compare the combination of erlotinib with pazopanib (providing concurrent EGFR and VEGFR inhibition) with erlotinib alone in the second- or third-line treatment of patients with advanced NSCLC. This study will be conducted though the Sarah Cannon Research Consortium, a community-based clinical trial network.
Timeline
- Start
- 2010-01
- Primary completion
- 2014-04
- Completion
- 2014-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Erlotinib | Small molecule | 150 mg | Oral |
| Subject | Pazopanib | Small molecule | 600 mg | Oral |