drugset / Trial / NCT01029769

Efficacy of an Early Antipsychotic Switch in Case of Poor Initial Response to the Treatment of Schizophrenia

NCT01029769

Completed 350 enrolled Technical University of Munich
RandomizedCrossoverTriple-blindTreatment

Summary

The main aim of the trial is to study whether a change of medication in non-responders to a two-weeks antipsychotic drug trial is more effective than continued treatment with the same antipsychotic. Hypothesis: Non-responders who are switched at 2 weeks to another antipsychotic are more frequently in symptomatic remission at week 8 than non-responders who stay on the same antipsychotic

Timeline

Start
2009-12
Primary completion
2014-03
Completion
2015-03

Drugs

EvaluationDrugModalityDoseRoute
Comparator Amisulpride Small molecule 200 mg Oral
Comparator Amisulpride Small molecule 800 mg Oral
Comparator Olanzapine Small molecule 5 mg Oral
Comparator Olanzapine Small molecule 20 mg Oral