drugset / Trial / NCT01029769
Efficacy of an Early Antipsychotic Switch in Case of Poor Initial Response to the Treatment of Schizophrenia
RandomizedCrossoverTriple-blindTreatment
Summary
The main aim of the trial is to study whether a change of medication in non-responders to a two-weeks antipsychotic drug trial is more effective than continued treatment with the same antipsychotic. Hypothesis: Non-responders who are switched at 2 weeks to another antipsychotic are more frequently in symptomatic remission at week 8 than non-responders who stay on the same antipsychotic
Timeline
- Start
- 2009-12
- Primary completion
- 2014-03
- Completion
- 2015-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amisulpride | Small molecule | 200 mg | Oral |
| Comparator | Amisulpride | Small molecule | 800 mg | Oral |
| Comparator | Olanzapine | Small molecule | 5 mg | Oral |
| Comparator | Olanzapine | Small molecule | 20 mg | Oral |