drugset / Trial / NCT01030367
Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients
Non-randomizedParallel-groupOpen-labelBasic science
Summary
Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.
Timeline
- Start
- 2007-01
- Primary completion
- 2008-11
- Completion
- 2010-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Isosorbide Dinitrate | Other / unclassified | 40 mg | Oral |
| Subject | PETN | Small molecule | 80 mg | Oral |