Synergistic Effect of Combination Therapy With Cilostazol and Probucol on Plaque Stabilization and Lesion Regression: Serial Intravascular Ultrasound and Virtual Histology Study(SECURE Study)

Phase 4 Completed 118 enrolled Yonsei University Korea Otsuka Pharmaceutical Co., Ltd. · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to evaluate the effect of combination therapy with cilostazol and probucol on plaque volume and composition change in comparison with cilostazol alone by serial intravascular ultrasound and virtual histology.

Timeline

Start: 2009-11
Primary completion: 2011-06
Completion: 2011-06

Publications

Ko YG, Kim BK, Lee BK, Kang WC, Choi SH, Kim SW, Lee JH, Lee M, Honda Y, Fitzerald PJ, Shim WH; SECURE Investigators. Study design and rationale of "Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)" study: a double-blind randomised controlled multicenter clinical trial. Trials. 2011 Jan 12;12:10. doi: 10.1186/1745-6215-12-10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Probucol	Small molecule	500 mg	—
Background	Cilostazol	Small molecule	200 mg	—

Indications

No indication recorded.